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It was reported that the mitochondrial protease AFG3L2 is a regulator of SLC25A39 protein

[DOI] [PMC free article] [PubMed] [Google Scholar] 24.Foitzik K., Lindner G., Mueller-Roever S., Maurer M., Botchkareva N., Botchkarev V., Handjiski B., Metz M., Hibino T., Soma T., et al

2023 titled Further evidence of relationship between thiamine blood level and cognition in chronic alcohol-dependent adults: Prospective Pilot Study of an inpatient detoxification with oral supplementation protocol, improvements in cognition and thiamine blood levels have been observed over about 14 days of supplementation

Stergiakouli E, Thapar A, Davey Smith G

And this "may slow the accumulation of plaque in the arteries," he says